منابع مشابه
Hormones and carcinogenesis
Hormones are important regulators of growth. By stimulating proliferation, hormones may increase the risk of mutation and at the same time stimulate the replication of the mutated cell. Thus, hormones are complete carcinogens. A direct carcinogenic effect of oestrogen in man is known from the occurrence of vaginal carcinomas in girls born of mothers who were treated with oestrogen during pregna...
متن کاملHormones and dietary fat as promoters in mammary carcinogenesis.
Hormones, particularly ovarian steroids and pituitary prolactin, promote mammary carcinogenesis in rats treated with a carcinogen. Hormones also play a critical role during the initiation process as demonstrated by mammary carcinogenesis in ovariectomized rats. A diet high in fat content, especially polyunsaturated fat, promotes mammary tumorigenesis when it is fed to carcinogen-treated rats fo...
متن کاملThe role of reproductive hormones in epithelial ovarian carcinogenesis.
Epithelial ovarian cancer comprises ∼85% of all ovarian cancer cases. Despite acceptance regarding the influence of reproductive hormones on ovarian cancer risk and considerable advances in the understanding of epithelial ovarian carcinogenesis on a molecular level, complete understanding of the biologic processes underlying malignant transformation of ovarian surface epithelium is lacking. Var...
متن کاملHormones and Sexual Disordors
The Paper is divided into two parts; at first: The role of endocrine system on anatomical development of internal and external sexual organs; Second part discusses the Endocrine View point of gender identity gender role, impotence, frigidity and other psychosexual disorders like homosexualism and transsexualism.
متن کاملBoth ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats.
August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammary cancers in ovary-intact ACI rats. To determine the role of progesterone in m...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1984
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1984.172